Dr shaf keshavjee biography samples

Jump to navigation. Shaf Keshavjee is a world-renowned thoracic surgeon-scientist with a history of breakthroughs and discoveries in lung transplantation. Keshavjee completed his medical training at the University of Toronto inand specialized in General Surgery, Cardiac Surgery and Thoracic Surgery. Keshavjee completed fellowships at Harvard University and the University of London.

Keshavjee developed a lung preservation solution for donor lungs that has now been translated into clinical use around the world. For Dr. Learn how your comment data is processed. Twitter Facebook Instagram.

Dr shaf keshavjee biography samples: Shaf KESHAVJEE, Professor |

Like Loading Author: ismailimail Independent, civil society media featuring Ismaili Muslim community, inter and intra faith endeavors, achievements and humanitarian works. Leave a comment Cancel reply. Search for: Search. Comment Reblog Subscribe Subscribed. His current studies examine molecular diagnostics and gene therapy strategies for engineering organs for lung transplantation.

Dr shaf keshavjee biography samples: Shaf's parents were born

The Lab's work explores the underlying mechanisms of ischemia-reperfusion injury and bronchiolitis obliterans — two areas that limit successful lung transplantation — and develops gene therapy strategies for either preventing or reversing them. Several areas within ischemia-reperfusion injury are examined, including the role of complement and cytokine-related lung injury and its relation to reperfusion.

The work is done on cell culture models, rat single lung transplant models, and pig single lung transplant models. Keshavjee and his research team have developed a technique of lung preservation that can improve lung function after its transplantation. The solution is made from low-potassium dextran and is used in the Ex Vivo. The LPD solution is applied in both the Toronto lung transplant program and in clinical programs around the world.

Keshavjee's research team focuses its main efforts on the role of gene therapy in lung transplantation.

Dr shaf keshavjee biography samples: Keshavjee is a surgeon and

They are currently developing techniques for genetically modifying the donor lung so it can withstand stress during the transplant process. Ultimately, these techniques would be used to address both ischemia-reperfusion injury and obliterative bronchiolitis. Keshavjee's work has demonstrated that immunosuppression related to transplantation leads to an altered expression of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.

To this effect, he and his team have proved that gene therapy will help recipients recover from lung transplantation surgery without a significant immune system response. When addressing obliterative bronchiolitis in a rat tracheal transplant model of fibrous airway obliteration related to transplantation, Keshavjee's research showed that the adenoviral IL gene transfection was able to prevent the development of bronchiolitis obliterans.

The team is currently studying the effect of the IL transfection on ischemia-reperfusion therapy, as well as mechanisms of cell death and the genes controlling the process. It began inand expanded to pediatric lung transplantation surgeries in Located in the Toronto General Hospital, it has gained international recognition for performing several remarkable firsts, including: First successful single-lung transplant, first successful double lung transplant, first pediatric lung transplant, first pediatric lung transplant with mismatched blood types, first to use an EXVIVO outside of the body, and the first to use the Novalung ventilator to provide more time for those awaiting transplantation.

As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate. A gene-therapy trial will begin next year. Donor lungs are placed in ice, with one tube attached to the pulmonary artery and another sewn to a vein used for training blood out of the lung. The lung is then moved onto a steel platform atop the device and hooked to a circuit with a ventilator and heart-lung mimicking machine that pumps the preservation solution into them.

As they are brought up to body temperature, they are healed with an anti-inflammatory solution developed by Keshavjee. Eventually, the lungs begin to inflate and deflate as they breathe on their own. For several hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow of fluid, and whether they are becoming less stiff.